White Blood Cell Count and Differential Count
(WBC and Diff)

Alternate Names

  • WBC Count
  • Leukocyte Count
  • White Count
  • WBC and Differential
  • Leukocyte Count

WBCs are produced in the bone marrow, and are necessary to fight infection and for normal immune response. A WBC count measures the total amount of WBCs in a specified amount of blood, while a Differential count measures specific WBCs as a percentage of the total WBC count, and allows for more specific diagnoses. The Absolute Count is the product of a mathematical calculation done in the lab, and is done as a further diagnostic tool. WBC and Diff are always done as part of a Complete Blood Count, which gives your doctor a lot of information concerning your general health, and is used to help diagnose illness, and to monitor how well you are responding to treatment.

There are five different WBCs and each have a different function in normal immunity. Neutrophils fight and eat bacteria and only live for a few hours. Basophils, mainly eosinophils, are released as a result of allergic reactions or the presence of parasites. Lymphocytes are divided into T cells and B cells; T cells are involved in immune reactions; B cells are involved in antibody production. Monocytes are similar to neutrophils, but they are produced very quickly and live longer. Low blood levels are seen in people with severe infections, inherited bone marrow disease, autoimmune disease, poor nutrition, non-functioning bone marrow, chemotherapy, or excessively high levels of some medications. High levels are seen in people with inflammation or infection, stress, trauma, or leukemia. There are many medications that can affect WBC levels.


Comments on White Blood Cell Count and Differential Count (4 total) Participate in the discussion

yatika chadha

Posted 8 years ago
Reply   Report spam

WBC differential count :eosinophiles-10% What does this mean?

1 replies


Posted 7 years ago
Reply   Report spam


0 replies


Posted 5 years ago
Reply   Report spam

9 year old has CBC eosinophils count of 3300. What could this mean?

0 replies


Posted 4 years ago
Reply   Report spam

hi,my child affect due to low count . what is the reamady for this problem

0 replies

In a medical emergency, step away from this web site and call for emergency help. Remember, we're not doctors and we don't claim to be able to diagnose your condition. The information and services we provide or display here are merely intended to make you a more knowledgeable patient so that you can have smarter conversations with your actual health care providers.